STRIDE validated in human in-vivo samples in collaboration with AstraZeneca
KRAKÓW, POLAND, 17 November 2023 – In the realm of DNA repair and targeted therapies, accurate detection and quantification of DNA damage are essential for evaluating drug PD effects and the efficacy of treatments. While conventional antibody-based IF methods have been widely employed in in vitro studies, they often face limitations when applied to clinical samples like FFPE tissue sections and liquid biopsies.
To address these challenges, intoDNA and AstraZeneca have collaborated on several experiments to validate STRIDE as a groundbreaking tool for analysing DNA breaks induced by DNA-damaging therapeutics and targeted DDR inhibitors.
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…and uncover insights from STRIDE assays performed in clinical samples.
Covered in this poster are:
- validation of STRIDE in PBMCs and FFPE tissue sections
- applicability of STRIDE across different types of tumours
- quantification of both endogenous DNA breaks and those induced by DNA-damaging therapeutics and DNA Damage Response (DDR) inhibitors