STRIDE™

DNA Damage
Detection Assays

Our assays offer direct and sensitive detection of the most deleterious type of DNA damage, DNA breaks. Coupled with accurate and objective quantification, these tools are a perfect fit for monitoring the delicate balance between DNA damage and repair.

Learn More

STRIDE™

DNA Damage
Detection Assays

Learn More

Advantages

Biologically proximal

STRIDE™ is designed to detect DNA ends directly at the site of DNA damage, providing a measurement that is independent of the DNA Damage Response, in contrast to classic surrogate protein markers.

Individual DNA break levels

STRIDE™ allows to quantify even a single DNA lesion, which translates into unprecedented sensitivity in measurements of the pharmacodynamic effects of drug candidates.

Selectivity you need

With STRIDE™ both single- or double-strand DNA breaks can be quantified, which contributes to better understanding of the mode of action of therapeutics impacting DNA integrity.

Spatially resolved DNA damage

STRIDE™ assays allow you to detect and quantify DNA ends at the sites of DNA breaks or cytosolic DNA fragments in selected subcellular compartments.

DNA Damage
Detection Assays

All the STRIDE™ measurements can be applied to quantify DNA damage and repair activity in the nucleus and in mitochondria as well as to quantify cytosolic DNA fragments.

SSBs

Detection of single-strand DNA breaks

sSTRIDE™

DSBs

Detection of double-strand DNA breaks

dSTRIDE™

We’ve also developed STRIDE™ assays detecting colocalization of DNA breaks and DNA repair proteins. These unique assays report on the status of a DNA repair pathway of interest.

Quantify protein-associated breaks

How STRIDE™ works

Proprietary STRIDE™ technology is a fluorescence-based method, which directly labels DNA damage sites and detects individual DNA lesions. Strong signal amplification allows for robust and reliable quantification of DNA damage, which translates into impactful values for your research and business.