Solutions & Services
+10K
0.5K+
100+
7/10
Solutions & Services
+10K
0.5K+
100+
7/10
Process Outline
01
Consultative Planning
In-depth consultations to understand your objectives, aligning our expertise with your goals
Collaborative hypothesis formulation to address your specific research questions
Customised project design integrating various conditions and controls for optimal outcome
02
Efficient Execution
Sample processing (cell culturing, FFPE block sectioning) and treatment
STRIDE™ multiplexed with co-stainings for robust results
High resolution 3D confocal imaging
03
Comprehensive Analysis
Precise STRIDE™ quantification using our advanced in-house algorithms
Hypothesis testing
Thorough analysis of findings and assessment of their biological relevance by subject experts
Descriptive statistics and regression analysis
04
Tailored Delivery
Diverse graphical data representation and custom visualisations
Compelling data storytelling
Data presentation highlighting key patterns for comprehensive understanding
Project finalization with a detailed report
Our Solutions
STRIDE™ DNA Damage Detection Assays
STRIDE™ DNA Repair Functional Assays
Flexible Application Across Drug Development Phases
STRIDE™ assays accompany every stage of the targeted therapeutics development process.
Make informed decisions, every step of the way. STRIDE™ assays guide your targeted therapeutics from concept to cure, from target validation, through screening of compounds, MoA assessment in in vitro and in vivo models, studies of pharmacodynamics, and PD biomarker development to functional predictive biomarker development and validation. Accelerate your path to market with actionable insights.
Research Model Compatibility
STRIDE™ technology is highly versatile and can be applied in a variety of biological materials analyzed at the intoDNA laboratory, including:
- fixed cell line models (grown and fixed on coverslips or multiwell plates, formalin-fixed paraffin-embedded cell pellets)
- formalin-fixed paraffin-embedded tissue sections (cell line-derived- and patient-derived xenografts, clinical samples)
- frozen tissue sections
- tissue and cell microarrays
- blood cell smears
- germ cells
- isolated blood cells
Multiplex STRIDE™ with Various Markers
PanCK
Cancer type-specific markers
Postpartum breast cancer tissues stained with dSTRIDE™ assay (pink) and PanCK (green)
Cancer type-specific markers
PanCK, Ki67, PSMA and More
CellMask™
Cytoplasmic & Mitochondrial markers
HeLa cells stained with dSTRIDE™ assay (pink), DAPI (blue), and CellMask™ (green)
Cytoplasmic & Mitochondrial markers
CellMask™, GAPDH, TOMM20 and More
PCNA
Cell cycle stage markers
A549 cells stained with dSTRIDE-RPA70™ assay (pink) and PCNA (green)
Cell cycle stage markers
PCNA, Cyclin B1, pHH3, and More
CD45
Immunity sensors
Co-culture of THP and LNCaP cells stained for CD45 (green) and nucleus with DAPI (blue)
Immunity sensors
CD45, pSTING and More
γH2AX
DNA repair marker
DLD1 cells stained with sSTRIDE™ assay (red), γH2AX (green), and DAPI (blue)
DNA repair marker
γH2AX, RAD51, RPA70 and More
Cleaved caspase-3
Cell death marker
HAP1 cells stained for cleaved caspase-3 (green) and nucleus with DAPI (blue)
Cell death marker
Caspase-3, Caspase-7 and More
Data Analysis Portfolio
intoDNA service includes automated image and data analysis at scale, delivering you an objective DNA damage quantification and a customized results presentation even with tight timelines.
Precision with High-Resolution 3D Images
because biology happens in 3 dimensionsUtilizing high-throughput Confocal Microscopy, our automation platform is capable of producing high-resolution 3D images.
Accuracy and Unbiased Results with cutting-edge AI technologies
because objectivity and reproducibility are our missionIn-house built automated image analysis algorithms guarantee objectivity and accuracy in fluorescence signals quantification.
Customizable Analysis
because you can look at data from different anglesTailored data analysis and data visualisation to dissect relevant information addressing your questions.
High-Throughput and Scalable Infrastructure
because we adapt to your needsOur infrastructure is designed to handle experiments of any size with high throughput.
Data-Driven Insights
because we base our conclusions on data onlyThrough advanced algorithms and statistical models, we ensure that the insights derived are based on objective data rather than subjective interpretations.
Secure Data Handling
because your data is precious to usOur commitment to maintaining the confidentiality and integrity of your information is reflected in every aspect of our data handling processes.
Our Analysis Spotlight
Objective signal detection
- In-house developed AI solutions accurately and objectively detect STRIDE™ foci
Accurate quantification
- Reliable quantification of DNA damage and repair activity in chosen cell compartments
Spatial colocalization
- Co-occurrence of DNA breaks with your protein of interest
Automated classification
- Selective characterization of cell subpopulations based on cell-cycle, cell-death or other markers
Robust segmentation
- Automated object detection and partitioning in 3D to segment nuclei, nucleoli, micronuclei, mitochondria, cytoplasm, and other cellular structures
DNA breaks in the nucleus
DNA fragments in the cytoplasmFIND OUT MORE
Case Studies
Development and validation of a customized, functional STRIDE-based assay to measure Mismatch Repair (MMR) pathway activity in cells
Studying the effects of alpha and beta-emitters alone and in combination with a DDR inhibitor in a human cell line model
Let’s talk about your project
Schedule a meeting with our scientific experts!