Selected Publications

Imaging of Hepatitis B Virus Nucleic Acids: Current Advances and Challenges

Luisa F Bustamante-Jaramillo, Joshua Fingal, Marie-Lise Blondot, Gustaf E Rydell, Michael Kann

DNA Double Strand Break and Response Fluorescent Assays: Choices and Interpretation

Jake Atkinson, Eva Bezak, Hien Le, Ivan Kempson

Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Samuel D Chauvin, Shoichiro Ando, Joe A Holley, Atsushi Sugie, Fang R Zhao, Subhajit Poddar, Rei Kato, Cathrine A Miner, Yohei Nitta, Siddharth R Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N Artyomov, David C Schultz, P Toby Coates, Elisha D O Roberson, Yasmine Belkaid, Roger A Greenberg, Sara Cherry, Michaela U Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J Miner

FEN1 is critical for rapid single-strand break repair in G1 phase

Kamila Burdova, Richard Hailstone, Hana Hanzlikova, Keith W Caldecott

Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryos

Nataliia Dudko, Jurek W Dobrucki, Helena Fulka

Quantitative Analysis of DNA Double‐Strand Breaks in Genomic DNA Using Standard Curve Method

Lihuang Guo, Hanying Dai, Jiancheng Li, Chenwei Li, Yue Huang, Keqian Xu

Critical assessment of microscopy methods for detecting single- and double-strand DNA breaks

Agnieszka Hoang-Bujnowicz, Julita Wesolowska, Agnieszka Ostromecka, Beata Nosal, Weronika Pawlus, Svitlana Levchenko, Miroslaw Zarebski, Jurek W. Dobrucki

XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance

Tulasigeri M. Totiger, Wannasiri Chiraphapphaiboon, Yasmine Baca, Sana Chaudhry, Ryan Q. Notti, Skye Montoya, Monika Chojnacka, Gabriel Gaidosh, Jumana Afaghani, Maurizio Affer, Christopher Armstrong, Paul Kavanaugh, Efe Karaca, Jenna Zabroski, Michael Lewis, Alyssa Maye, Jacob Jahn, Rajesh K. Soni, Daniel Bilbao, Phil Walker, Andrew Elliott, Emil Lou, Wafik S. El-Deiry, Jose Antonio Rodriguez, Hai Dang Nguyen, Justin Taylor

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes MelphalanInduced DNA Double-Strand Breaks in Uveal Melanoma

Iuliia Pavlyk, George Field, Matthew Young, Josephine Carpentier, Emilia A. Szlosarek, Michaela R. O'Keeffe-Brown, Timothy Crook, Nelofer Syed, John S. Bomalaski, Pui Ying Chan, Peter W. Szlosarek

#19 Unifying Drug Discovery Insights with STRIDE®

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Mytho/Phaf1 is required to prevent DNA damage and tissue degeneration in Danio rerio

Tommaso Pagliarusco, Anais Franco-Romero, Francesca Terrin, Filippo Citton, Ludovica Carducci, Nicola Facchinello, Camilla Maria Fontana, Marta Giacomazzo, Ranieri Verin, Maria Berica Rasotto, Lisa Locatello, Luisa Dalla Valle & Marco Sandri

#18 More Therapy Options for Patients: Decentralizing HR Testing with dSTRIDE-HR

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#17 Introducing dSTRIDE™-HR: See HR Repair in Real Time

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#16 Why 80% of Patients are Denied Personalized Care

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#15 5x FASTER Drug Development Timelines

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#14 STRIDE™ Cuts R&D Costs by 40%

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#13 The impact of DNA damage on neuronal decline

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In situ measurement of PARP1 activity and trapping at single-strand DNA breaks

Franek Sierpowski, Katarzyna Fryt, Jakub Lechowski, Zsombor Prucsi, Magdalena Kordon-Kiszala, Kamil Solarczyk

Direct measurement of NER activity using sSTRIDE-NER

Olga Wójcikowska, Julita Imioło, Magdalena Bartyńska, Zsombor Prucsi, Magdalena Kordon-Kiszala, Kamil Solarczyk

#12 Can Measuring DNA Damage Unlock Longevity?

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#11 DNA Damage and Repair: The Hidden Driver Across Medicine

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#10 An Old Idea Behind New Cancer Breakthroughs

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#09 Cutting Waiting Times in Biomarker Testing with STRIDE®

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#8 Biomarkers at the Heart of Precision Medicine

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In situ detection of WRN activity and R-Loop accumulation at DNA double-strand breaks using the dSTRIDE™ platform

O. Wójcikowska, E. Szafraniec, M. Bartyńska, M. Białecka, Z. Prucsi, M. Kordon-Kiszala, K. Solarczyk

Androgen receptor inhibition extends PARP inhibitor activity in prostate cancer models beyond BRCA mutations and defects in homologous recombination repair

Giuditta Illuzzi, Alessandro Galbiati, Anna D. Staniszewska, Robert Hanson, Chrysiis Michaloglou, Sophie L. Cooke, Karolina Uznanska, Maja Białecka, Kamil Solarczyk, Harveer S. Dev, Charlie E. Massie, Mark R. Albertella, Elisabetta Leo, Josep V. Forment, Mark J. O’Connor

#7 How STRIDE® Detects Cancer’s DNA Repair Weakness

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#6 Visualizing DNA Repair: The STRIDE® Technology Explained

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#5 Beyond Genomic Scars: The Future of Biomarkers for Cancer Therapy

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#4 Predicting Treatment Success: A Biomarker Strategy for DDR Inhibitors

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#3 Seeing DNA Breaks with X-Ray Precision: How STRIDE® Transforms DNA Damage Detection

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#2 DNA Damage Biomarkers: Measuring the Impact of DDR Inhibitors with STRIDE®

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#1 Turning DNA Repair into a Therapeutic Strategy: Precision Oncology with STRIDE®

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Replication stress detection using STRIDE® technology platform

K. Stepien, K. Schirmeisen, D. Jaśniak, Z. Prucsi, J. Lechowski, M. Bartyńska, M. Kordon-Kiszala, K. Solarczyk

STRIDE™: a platform for quantitative DNA damage response dissection

M. Białecka, O. Wójcikowska, K. Białas, D. Jaśniak, J. Lechowski, M. Bartyńska, K. Stepien, F. Sierpowski, K. Schirmeisen, Z. Prucsi, A. Waligórska, M. Kordon-Kiszala, K. Solarczyk

STRIDE™: Overcoming the limitations of γH2AX as a DNA damage detection method

K. Białas, O. Wójcikowska, D. Jaśniak, M. Bartyńska, J. Lechowski, S. Ostrowska-Paton, Z. Prucsi, I. Aylott, M. Białecka, A. Waligórska, M. Kordon-Kiszala, K. Solarczyk

Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation

Gál, Z., Boukoura, S., Oxe, K.C. et al.

STRIDE® DNA Damage Response Assays by Kamil Solarczyk — the CTO and a co-Founder of intoDNA.

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STRIDE® in DNA Damage Analysis by Magda Kordon — the CEO and a co-Founder of intoDNA.

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STRIDE™ as a technology platform for accurate measurement of DNA breaks and breaks-associated repair proteins (AACR Synthetic Lethality Special Conference 2024)

A. Uherek, K. Stępień, O. Wójcikowska, K. Solarczyk, et al.

LP-184, a Novel Acylfulvene Molecule, Exhibits Anticancer Activity against Diverse Solid Tumors with Homologous Recombination Deficiency

A. Kulkarni, J. Zhou, Z. Prucsi, K. Solarczyk, et al.

Novel dSTRIDE™-HR assays can accurately assess DNA repair defects in human cancers and distinguish HR status of tumors (AACR 2024)

M. Jarosz, Z. Prucsi, F. Sierpowski, K. Solarczyk, et al.

Measuring the activity of SMUG1 DNA glycosylase with a novel sSTRIDE™-SMUG1 assay (AACR 2024)

K. Stępień, F. Sierpowski, Z. Prucsi, K. Solarczyk, et al.

Studying the MoA of the next generation chemotherapeutic LP-284, a small molecule acylfulvene in a chronic myelogenous leukemia cell line model using STRIDE™

Studying the effects of alpha and beta-emitters alone and in combination with a DDR inhibitor in a human cell line model

Studying the MoA of a DDR inhibitor in Patient-Derived Xenograft (PDX) models using STRIDE®

DNA damage levels in development of DDR inhibitors — why gammaH2AX is not enough?

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Detection of DNA damage using STRIDE® as a new PD biomarker in liquid biopsies and FFPE tissue sections

K. Solarczyk, A. Waligórska, M. Szczygieł, P. Waring, G. Jones, et al.

Development and validation of a customized, functional STRIDE®-based assay to measure Mismatch Repair (MMR) pathway activity in cells

sSTRIDE™ as a technology platform for the detection and measurement of DNA breaks in various DNA repair pathways (DDR Inhibitors Summit 2024)

M. Białecka, K. Uznańska, O. Wójcikowska, K. Solarczyk, et al.

LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin’s lymphoma models and in cells deficient in DNA damage repair

J. Zhou, D. Sturtevant, C. Love, A. Kulkarni, K. Bhatia, et al.

Development and validation of a novel sSTRIDE™-MMR functional assay to study the efficiency of MMR inhibitors (AACR 2023)

M. Białecka, K. Solarczyk, K. Uznańska, O. Wójcikowska, et al.

Novel functional dSTRIDE™-HR assays to report on the status of homologous recombination repair in cancer cells (AACR 2023)

K. Solarczyk, A. Waligórska, K. Uznańska, Z. Prucsi, et al.

Let’s not take DNA breaks for granted. The importance of direct detection of DNA breaks for the successful development of DDR inhibitors

M. Kordon-Kiszala and K. Solarczyk

Ubiquitinated PCNA drives USP1 synthetic lethality in cancer

A. Simoneau, J. Engel, M. Bandi, K. Lazarides, S. Liu, et al.

Breakage of CRISPR/Cas9-Induced Chromosome Bridges in Mitotic Cells

M. Rodriguez-Muñoz, M. Serrat, D. Soler, A. Genescà and T. Anglada

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

J. Gozgit, M. Vasbinder, R. Abo, K. Kunii, K. Kuplast-Barr, et al.

intoDNA — meet STRIDE®

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STRIDE—a fluorescence method for direct, specific in situ detection of individual single- or double-strand DNA breaks in fixed cells

M. Kordon-Kiszala, M. Zarębski, K. Solarczyk, H. Ma, T. Pederson, J. Dobrucki