Progress in science depends on new techniques, new discoveries and new ideas, probably in that order. Sydney Brenner
We are proud to present STRIDE – a novel, direct, super-sensitive method of detection of DNA breaks.
SensiTive Recognition of Individual DNA Ends
STRIDE is very sensitive
It is capable of detecting even just one DNA strand break inside the cell nucleus.
STRIDE is highly specific
It detects exclusively DNA breaks, and no other type of damage.
STRIDE is selective
STRIDE technology embraces two methods - sSTRIDE which can detect single-strand breaks, and dSTRIDE which detects double-strand DNA breaks.
The unprecedented sensitivity and specificity of STRIDE technology is derived from direct fluorescent labelling of open DNA ends in a newly induced break, strong signal amplification, and elimination of the nonspecific background. Since STRIDE is based on fluorescence, it can be adapted to various detection strategies, including fluorescence microscopy, confocal microscopy, flow cytometry, high-throughput screening, etc.
dSTRIDE and sSTRIDE have potential to be used in: