Solutions

Progress in science depends on new techniques, new discoveries and new ideas, probably in that order. Sydney Brenner

We are proud to present STRIDE – a novel, direct, super-sensitive method of detection of DNA breaks.

STRIDE

SensiTive Recognition of Individual DNA Ends

STRIDE is very sensitive

It is capable of detecting even just one DNA strand break inside the cell nucleus.

STRIDE is highly specific

It detects exclusively DNA breaks, and no other type of damage.

STRIDE is selective

STRIDE technology embraces two methods - sSTRIDE which can detect single-strand breaks, and dSTRIDE which detects double-strand DNA breaks.

The unprecedented sensitivity and specificity of STRIDE technology is derived from direct fluorescent labelling of open DNA ends in a newly induced break, strong signal amplification, and elimination of the nonspecific background. Since STRIDE is based on fluorescence, it can be adapted to various detection strategies, including fluorescence microscopy, confocal microscopy, flow cytometry, high-throughput screening, etc.



Scheme of a cell and dSTRIDE image A schematic drawing of a single cell grown in an in vitro culture, and a fluorescence image of dSTRIDE signals, representing double-strand DNA breaks, overlayed on a transmitted light image of the cell.



dSTRIDE and sSTRIDE have potential to be used in:

Take a break. Have a look at it with us.

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